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- Table of Contents
Facts about Double-strand break repair protein MRE11.
RAD50 could be asked to bind DNA ends and hold them in close proximity. This may facilitate searches for long or short regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to stop nucleolytic degradation beyond a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289).
Human | |
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Gene Name: | MRE11 |
Uniprot: | P49959 |
Entrez: | 4361 |
Belongs to: |
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MRE11/RAD32 family |
ATLDmeiotic recombination (S. cerevisiae) 11 homolog A; AT-like disease; DNA recombination and repair protein; double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog 1; MRE11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Mre11; MRE11A; MRE11MRE11B
Mass (kDA):
80.593 kDA
Human | |
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Location: | 11q21 |
Sequence: | 11; NC_000011.10 (94415570..94512701, complement) |
Nucleus. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents.
PMID: 8530104 by Petrini J.H.J., et al. Isolation and characterization of the human MRE11 homologue.
PMID: 9651580 by Paull T.T., et al. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.